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Article

Accelerated Accumulation of Lipofuscin Pigments in the RPE of a Mouse Model for<i>ABCA4</i>-Mediated Retinal Dystrophies following Vitamin A Supplementation

1 Sept 2008

Abstract excerpt

PURPOSE: Dietary supplementation with vitamin A is sometimes prescribed as a treatment for retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive blindness. Loss-of-function mutations in the ABCA4 gene are responsible for a subset of recessive retinitis pigmentosa. Other mutant alleles of ABCA4 cause the related diseases, recessive cone-rod dystrophy, and recessive Stargardt...

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PMID: 18515570
DOI: 10.1167/iovs.07-1470

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