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Article

Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration

5 Apr 2004

Abstract excerpt

Recessive Stargardt's macular degeneration is a blinding disease of children caused by mutations in the ABCA4 (ABCR) gene. Mice with a knockout mutation in abcr accumulate toxic lipofuscin pigments in ocular tissues, similar to affected humans. The major fluorophore of lipofuscin is the bis-retinoid, N-retinylidene-N-retinylethanolamine (A2E). In the current study, we sought to define the effect of increasing...

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PMID: 15067110
DOI: 10.1073/pnas.0308302101

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Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degenerationPMID 15067110Read ↗

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