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Three hundred and seventy-two novel HLA class II alleles identified in potential hematopoietic stem cell donors from Germany, the United States, and Poland.

Tissue antigens - 1 Nov 2014

Hernández-Frederick C J, Cereb N, Giani A S, Ruppel J, Maraszek A, Pingel J, Sauter J, Schmidt A H, Yang S Y

Abstract excerpt

We have characterized 372 novel human leukocyte antigen (HLA) class II alleles identified in newly registered stem cell donors, this includes 281 HLA-DRB1 alleles, 89 HLA-DQB1 alleles and 2 HLA-DPB1 alleles. Most novel alleles were single nucleotide variants when compared to their respective most homologous alleles. In 66.4% of all novel alleles non-synonymous nucleotide variations were identified, in 30.4%...

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PMID: 25220445
DOI: 10.1111/tan.12432

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