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Article

G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction.

Glycobiology - 1 Jul 2011

Hayee Bu'hussain, Antonopoulos Aristotelis, Murphy Emma J, Rahman Farooq Z, Sewell Gavin, Smith Bradley N, McCartney Sara, Furman Mark, Hall Georgina, Bloom Stuart L, Haslam Stuart M, Morris Howard R, Boztug Kaan, Klein Christoph, Winchester Bryan, Pick Edgar, Linch David C, Gale Rosemary E, Smith Andrew M, Dell Anne, Segal Anthony W

Abstract excerpt

Glucose-6-phosphatase, an enzyme localized in the endoplasmic reticulum (ER), catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate. In humans, there are three differentially expressed glucose-6-phosphatase catabolic genes (G6PC1-3). Recently, it has been shown...

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Identifiers

PMID: 21385794
DOI: 10.1093/glycob/cwr023
PMCID: PMC3110488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21385794-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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