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Article

Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding.

BMC bioinformatics - 1 Jan 2013

Li Zhenhua, He Ying, Liu Qian, Zhao Liang, Wong Limsoon, Kwoh Chee Keong, Nguyen Hung, Li Jinyan

Abstract excerpt

BACKGROUND: Human triosephosphate isomerase (HsTIM) deficiency is a genetic disease caused often by the pathogenic mutation E104D. This mutation, located at the side of an abnormally large cluster of water in the inter-subunit interface, reduces the thermostability of the enzyme. Why and how these water molecules are directly related to the excessive thermolability of the mutant have not been investigated in...

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Identifiers

PMID: 24564410
DOI: 10.1186/1471-2105-14-S16-S11
PMCID: PMC3853089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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