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Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase.

Archives of biochemistry and biophysics - 1 Nov 2024

Romero Jorge Miguel

Abstract excerpt

Human triosephosphate isomerase G122R, also known as TPI-Manchester, is a thermolabile variant detected in a screening of more than 3400 individuals from a population in Ann Arbor, Michigan. Here, the crystallographic structure of G122R was solved to determine the molecular basis of its thermal stability. Structural analysis revealed an increase in the flexibility of residues at the dimer interface, even though...

Topics

Triose-Phosphate Isomerase
Humans
Crystallography, X-Ray
Enzyme Stability
Models, Molecular
Protein Multimerization
Protein Conformation
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39299479
DOI: 10.1016/j.abb.2024.110156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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