Article
Detecting gene mutations in Japanese Alzheimer's patients by semiconductor sequencing.
Neurobiology of aging - 1 Jul 2014
Yagi Ryoichi, Miyamoto Ryosuke, Morino Hiroyuki, Izumi Yuishin, Kuramochi Masahito, Kurashige Takashi, Maruyama Hirofumi, Mizuno Noriyoshi, Kurihara Hidemi, Kawakami Hideshi
Abstract excerpt
Alzheimer's disease (AD) is the most common form of dementia. To date, several genes have been identified as the cause of AD, including PSEN1, PSEN2, and APP. The association between APOE and late-onset AD has also been reported. We here used a bench top next-generation sequencer, which uses an integrated semiconductor device, detects hydrogen ions, and operates at a high-speed using nonoptical technology. We...
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