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Article

Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment.

PLoS biology - 1 Feb 2014

Kaiser Patrick, Regoes Roland R, Dolowschiak Tamas, Wotzka Sandra Y, Lengefeld Jette, Slack Emma, Grant Andrew J, Ackermann Martin, Hardt Wolf-Dietrich

Abstract excerpt

In vivo, antibiotics are often much less efficient than ex vivo and relapses can occur. The reasons for poor in vivo activity are still not completely understood. We have studied the fluoroquinolone antibiotic ciprofloxacin in an animal model for complicated Salmonellosis. High-dose ciprofloxacin treatment efficiently reduced pathogen loads in feces and most organs. However, the cecum draining lymph node (cLN),...

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Identifiers

PMID: 24558351
DOI: 10.1371/journal.pbio.1001793
PMCID: PMC3928039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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