Article
Morphology predicts BRAF (V⁶⁰⁰E) mutation in papillary thyroid carcinoma: an interobserver reproducibility study.
Virchows Archiv : an international journal of pathology - 1 Apr 2014
Virk Renu K, Theoharis Constantine G A, Prasad Avinash, Chhieng David, Prasad Manju L
Abstract excerpt
Papillary thyroid carcinomas (PTC) with BRAF (V600E) mutation are morphologically distinctive. They are typically classic or tall cell variants, show infiltrative borders, and are associated with desmoplasia/fibrosis, psammoma bodies, and well-developed nuclear features of papillary carcinoma. We hypothesize that morphologic features of PTC can help in the prediction of BRAF (V600E) mutation, and we evaluate the...
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