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Article

Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study.

Virchows Archiv : an international journal of pathology - 1 Apr 2024

Kim Chankyung, Agarwal Shipra, Bychkov Andrey, Hang Jen-Fan, Harahap Agnes Stephanie, Hirokawa Mitsuyoshi, Kakudo Kennichi, Keelawat Somboon, Liu Chih-Yi, Liu Zhiyan, Nguyen Truong Phan-Xuan, Rana Chanchal, Vuong Huy Gia, Zhu Yun, Jung Chan Kwon

Abstract excerpt

Differentiating BRAF V600E- and RAS-altered encapsulated follicular-patterned thyroid tumors based on morphology remains challenging. This study aimed to validate an 8-score scale nuclear scoring system and investigate the importance of nuclear pseudoinclusions (NPIs) in aiding this differentiation. A cohort of 44 encapsulated follicular-patterned tumors with varying degrees of nuclear atypia and confirmed BRAF...

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PMID: 38366204
DOI: 10.1007/s00428-024-03761-4

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