Article
Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.
The Journal of biological chemistry - 23 Mar 2012
Kondo-Okamoto Noriko, Noda Nobuo N, Suzuki Sho W, Nakatogawa Hitoshi, Takahashi Ikuko, Matsunami Miou, Hashimoto Ayako, Inagaki Fuyuhiko, Ohsumi Yoshinori, Okamoto Koji
Abstract excerpt
Autophagy-related degradation selective for mitochondria (mitophagy) is an evolutionarily conserved process that is thought to be critical for mitochondrial quality and quantity control. In budding yeast, autophagy-related protein 32 (Atg32) is inserted into the outer membrane of mitochondria with its N- and C-terminal domains exposed to the cytosol and mitochondrial intermembrane space, respectively, and plays...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.