Article
Recovering power in association mapping panels with variable levels of linkage disequilibrium.
Genetics - 1 May 2014
Rincent Renaud, Moreau Laurence, Monod Hervé, Kuhn Estelle, Melchinger Albrecht E, Malvar Rosa A, Moreno-Gonzalez Jesus, Nicolas Stéphane, Madur Delphine, Combes Valérie, Dumas Fabrice, Altmann Thomas, Brunel Dominique, Ouzunova Milena, Flament Pascal, Dubreuil Pierre, Charcosset Alain, Mary-Huard Tristan
Abstract excerpt
Association mapping has permitted the discovery of major QTL in many species. It can be applied to existing populations and, as a consequence, it is generally necessary to take into account structure and relatedness among individuals in the statistical model to control false positives. We analytically studied power in association studies by computing noncentrality parameter of the tests and its relationship with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.