Article
Imputing observed blood pressure for antihypertensive treatment: impact on population and genetic analyses.
American journal of hypertension - 1 Jun 2014
Rana Brinda K, Dhamija Anish, Panizzon Matthew S, Spoon Kelly M, Vasilopoulos Terrie, Franz Carol E, Grant Michael D, Jacobson Kristen C, Kim Kathleen, Lyons Michael J, McCaffery Jeanne M, Stein Phyllis K, Xian Hong, O'Connor Daniel T, Kremen William S
Abstract excerpt
BACKGROUND: Elevated blood pressure (BP), a heritable risk factor for many age-related disorders, is commonly investigated in population and genetic studies, but antihypertensive use can confound study results. Routine methods to adjust for antihypertensives may not sufficiently account for newer treatment protocols (i.e., combination or multiple drug therapy) found in contemporary cohorts. METHODS: We refined an...
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