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Finding the needle in the haystack: differentiating "identical" twins in paternity testing and forensics by ultra-deep next generation sequencing.

Forensic science international. Genetics - 1 Mar 2014

Weber-Lehmann Jacqueline, Schilling Elmar, Gradl Georg, Richter Daniel C, Wiehler Jens, Rolf Burkhard

Abstract excerpt

Monozygotic (MZ) twins are considered being genetically identical, therefore they cannot be differentiated using standard forensic DNA testing. Here we describe how identification of extremely rare mutations by ultra-deep next generation sequencing can solve such cases. We sequenced DNA from sperm samples of two twins and from a blood sample of the child of one twin. Bioinformatics analysis revealed five single...

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PMID: 24528578
DOI: 10.1016/j.fsigen.2013.10.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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