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Article

Are peripheral purely undifferentiated pleomorphic sarcomas with MDM2 amplification dedifferentiated liposarcomas?

The American journal of surgical pathology - 1 Mar 2014

Le Guellec Sophie, Chibon Frédéric, Ouali Monia, Perot Gaëlle, Decouvelaere Anne-Valérie, Robin Yves-Marie, Larousserie Frédérique, Terrier Philippe, Coindre Jean-Michel, Neuville Agnès

Abstract excerpt

Dedifferentiated liposarcoma (DDLPS) has been defined as a tumor composed of well-differentiated liposarcoma associated with a nonlipogenic undifferentiated sarcoma and is genetically characterized by a 12q13-15 amplicon with MDM2 amplification. Some peripheral (extremities, trunk wall, head/neck) undifferentiated pleomorphic sarcomas (UPS) without areas of well-differentiated liposarcoma present an MDM2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24525499
DOI: 10.1097/PAS.0000000000000131

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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