Article
Failure to detect functional neutrophil B helper cells in the human spleen.
PloS one - 1 Jan 2014
Nagelkerke Sietse Quirijn, aan de Kerk Daan Jacob, Jansen Machiel Hugo, van den Berg Timo Kars, Kuijpers Taco Willem
Abstract excerpt
A novel role for human neutrophilic granulocytes was recently described, showing that these cells, upon entering the spleen, can be reprogrammed into a distinct B cell-helper neutrophil phenotype that is capable of eliciting B cell responses such as immunoglobulin secretion, class switch recombination and somatic hypermutation. Using similar protocols, we detected a homogeneous population of CD15(high)CD16(high)...
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