Article
PhosphoTyrosyl phosphatase activator of Plasmodium falciparum: identification of its residues involved in binding to and activation of PP2A.
International journal of molecular sciences - 11 Feb 2014
Vandomme Audrey, Fréville Aline, Cailliau Katia, Kalamou Hadidjatou, Bodart Jean-François, Khalife Jamal, Pierrot Christine
Abstract excerpt
In Plasmodium falciparum (Pf), the causative agent of the deadliest form of malaria, a tight regulation of phosphatase activity is crucial for the development of the parasite. In this study, we have identified and characterized PfPTPA homologous to PhosphoTyrosyl Phosphatase Activator, an activator of protein phosphatase 2A which is a major phosphatase involved in many biological processes in eukaryotic cells....
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