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Article

BCOR Mutations Deregulate Cell Cycle and Hypoxic Adaptation Pathways in Retinoblastoma.

Molecular cancer research : MCR - 3 Mar 2026

Zhang Michelle G, Kuznetsoff Jeffim N, Cetta Natalie C, Salazar Sebastian, Volonterio Renata L, Kurtenbach Stefan, Correa Zelia M, Pelaez Daniel, Harbour J William

Abstract excerpt

Retinoblastoma is the most common pediatric eye cancer. Most cases of retinoblastoma are initiated by biallelic mutational inactivation of the RB1 gene, yet most retinoblastoma tumors harbor additional genomic aberrations that may promote tumor progression. After RB1, the gene that is most commonly mutated gene in retinoblastoma is BCOR, which is mutated in approximately 20% of retinoblastoma tumors and is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41191430
DOI: 10.1158/1541-7786.MCR-24-1078
PMCID: PMC12782302

Genes

BCOR
RB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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