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Article

Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.

Cellular & molecular immunology - 1 Mar 2014

Siu Kam-Leung, Chan Chi-Ping, Kok Kin-Hang, Chiu-Yat Woo Patrick, Jin Dong-Yan

Abstract excerpt

Coronaviruses have developed various measures to evade innate immunity. We have previously shown that severe acute respiratory syndrome (SARS) coronavirus M protein suppresses type I interferon (IFN) production by impeding the formation of functional TRAF3-containing complex. In this study, we demonstrate that the IFN-antagonizing activity is specific to SARS coronavirus M protein and is mediated through its...

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Source

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Identifiers

PMID: 24509444
DOI: 10.1038/cmi.2013.61
PMCID: PMC4003381

Genes

TRAF3
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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