Article
A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo.
Oncology reports - 1 Apr 2014
Chen Luyue, Zhang Kailiang, Shi Zhendong, Zhang Anling, Jia Zhifan, Wang Guangxiu, Pu Peiyu, Kang Chunsheng, Han Lei
Abstract excerpt
microRNA (miRNA) sponges are RNA molecules with repeated miRNA binding sequences that can sequester miRNAs from their endogenous target mRNAs, and a stably expressed miRNA sponge is particularly valuable for long-term loss-of-function studies in vitro and in vivo. Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and is characterized by extraordinarily angiogenic, invasive and...
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