Article
Vitamin D receptor genetics on extracellular matrix biomarkers and hemodynamics in systolic heart failure.
Journal of cardiovascular pharmacology and therapeutics - 1 Sept 2014
Dorsch Michael P, Nemerovski Carrie W, Ellingrod Vicki L, Cowger Jennifer A, Dyke D Bradley, Koelling Todd M, Wu Audrey H, Aaronson Keith D, Simpson Robert U, Bleske Barry E
Abstract excerpt
INTRODUCTION: Vitamin D deficiency has been associated with the development of myocardial hypertrophy and inflammation. These findings suggest that vitamin D status and vitamin D receptor (VDR) genomics may play a role in myocardial fibrosis. The aim of this pilot study was to determine the association between vitamin D levels, VDR polymorphisms, and biomarkers of left ventricular remodeling and hemodynamics....
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