Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100

4 Jan 2018

Abstract excerpt

Rationale: Genome-wide association studies identified single-nucleotide polymorphisms near the SORT1 locus strongly associated with decreased plasma LDL-C (low-density lipoprotein cholesterol) levels and protection from atherosclerotic cardiovascular disease and myocardial infarction. The minor allele of the causal SORT1 single-nucleotide polymorphism locus creates a putative C/EBPα (CCAAT/enhancer-binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Lysosomal Storage Disorders Research
Share to Nuclear Structure and Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29301854
DOI: 10.1161/circresaha.117.311240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100PMID 29301854Read ↗

Sortilin and lipoprotein metabolism: making sense out of complexity.Semantic proximity Read ↗

New insight into sortilin in controlling lipid metabolism and the risk of atherogenesisSemantic proximity Read ↗

Sortilin as a regulator of lipoprotein metabolism.Semantic proximity Read ↗

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.Semantic proximity Read ↗

Sortilin: the mechanistic link between genes, cholesterol, and coronary artery disease.Semantic proximity Read ↗

Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism.Semantic proximity Read ↗

Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male miceSemantic proximity Read ↗

Sortilin, Encoded by the Cardiovascular Risk Gene SORT1, and Its Suggested Functions in Cardiovascular DiseaseSemantic proximity Read ↗

The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin.Semantic proximity Read ↗

Genome-wide association studies identify new targets in cardiovascular disease.Semantic proximity Read ↗

Mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia.Semantic proximity Read ↗

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.