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Article

A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila.

Sleep - 1 Apr 2008

Wu Mark N, Koh Kyunghee, Yue Zhifeng, Joiner William J, Sehgal Amita

Abstract excerpt

STUDY OBJECTIVES: In order to characterize the genetic mechanisms underlying sleep, we have carried out a large-scale screen in Drosophila to identify short-sleeping mutants. The objectives of this study were as follows: (1) characterize the phenotypes of the shortest-sleeping mutants; (2) examine whether changes in arousal threshold or sleep homeostasis underlie short-sleeping phenotypes; (3) clone a gene...

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Identifiers

PMID: 18457233
DOI: 10.1093/sleep/31.4.465
PMCID: PMC2279757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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