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Article

Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts.

The Journal of investigative dermatology - 1 Sept 2014

Dumit Verónica I, Küttner Victoria, Käppler Jakob, Piera-Velazquez Sonsoles, Jimenez Sergio A, Bruckner-Tuderman Leena, Uitto Jouni, Dengjel Jörn

Abstract excerpt

Aging is a common risk factor of many disorders. With age, the level of insoluble extracellular matrix increases leading to increased stiffness of a number of tissues. Matrix accumulation can also be observed in fibrotic disorders, such as systemic sclerosis (SSc). Although the intrinsic aging pr...

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Source

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Identifiers

PMID: 24496236
DOI: 10.1038/jid.2014.69
PMCID: PMC4121389

Genes

MCM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24496236-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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