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Article

A chondromimetic microsphere for in situ spatially controlled chondrogenic differentiation of human mesenchymal stem cells.

Journal of controlled release : official journal of the Controlled Release Society - 10 Apr 2014

Ansboro Sharon, Hayes Jessica S, Barron Valerie, Browne Shane, Howard Linda, Greiser Udo, Lalor Pierce, Shannon Fintan, Barry Frank P, Pandit Abhay, Murphy J Mary

Abstract excerpt

Human mesenchymal stem cells (hMSCs) have been identified as a viable cell source for cartilage tissue engineering. However, to undergo chondrogenic differentiation hMSCs require growth factors, in particular members of the transforming growth factor beta (TGF-β) family. While in vitro differentiation is feasible through continuous supplementation of TGF-β3, mechanisms to control and drive hMSCs down the...

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PMID: 24491910
DOI: 10.1016/j.jconrel.2014.01.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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