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In vitro screening of embryos by whole-genome sequencing: now, in the future or never?

2 Feb 2014

Abstract excerpt

STUDY QUESTION: What are the analytical and clinical validity and the clinical utility of in vitro screening of embryos by whole-genome sequencing? SUMMARY ANSWER: At present there are still many limitations in terms of analytical and clinical validity and utility and many ethical questions remain. WHAT IS KNOWN ALREADY: Whole-genome sequencing of IVF/ICSI embryos is technically possible. Many loss-of-function...

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PMID: 24491297
DOI: 10.1093/humrep/deu005

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