Article
Telomere length as a risk factor for hereditary prostate cancer.
The Prostate - 1 Apr 2014
Hurwitz Lauren M, Heaphy Christopher M, Joshu Corinne E, Isaacs William B, Konishi Yuko, De Marzo Angelo M, Isaacs Sally D, Wiley Kathy E, Platz Elizabeth A, Meeker Alan K
Abstract excerpt
BACKGROUND: Telomeres are repetitive nucleotide sequences that stabilize the ends of chromosomes. Critically short telomeres are thought to contribute to cancer development by increasing chromosomal instability. We hypothesized that shorter leukocyte telomere length, a surrogate for inherited prostate cell telomere length, would be associated with increased risk of prostate cancer in hereditary prostate cancer...
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