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Article

Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.

PloS one - 1 Jan 2014

Murakami Akiko, Takahashi Fumiyuki, Nurwidya Fariz, Kobayashi Isao, Minakata Kunihiko, Hashimoto Muneaki, Nara Takeshi, Kato Motoyasu, Tajima Ken, Shimada Naoko, Iwakami Shin-ichiro, Moriyama Mariko, Moriyama Hiroyuki, Koizumi Fumiaki, Takahashi Kazuhisa

Abstract excerpt

Accumulating evidence indicates that a small population of cancer stem cells (CSCs) is involved in intrinsic resistance to cancer treatment. The hypoxic microenvironment is an important stem cell niche that promotes the persistence of CSCs in tumors. Our aim here was to elucidate the role of hypo...

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Source

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Identifiers

PMID: 24489728
DOI: 10.1371/journal.pone.0086459
PMCID: PMC3904884

Genes

EGFR
IGF1
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24489728-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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