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Article

Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.

Biochemical and biophysical research communications - 22 Apr 2016

Kobayashi Isao, Takahashi Fumiyuki, Nurwidya Fariz, Nara Takeshi, Hashimoto Muneaki, Murakami Akiko, Yagishita Shigehiro, Tajima Ken, Hidayat Moulid, Shimada Naoko, Suina Kentaro, Yoshioka Yasuko, Sasaki Shinichi, Moriyama Mariko, Moriyama Hiroyuki, Takahashi Kazuhisa

Abstract excerpt

Several recent studies have suggested that cancer stem cells (CSCs) are involved in resistance to gefitinib in non-small cell lung cancer (NSCLC). Oct4, a member of the POU-domain transcription factor family, has been shown to be involved in CSC properties of various cancers. We previously reported that Oct4 and the putative lung CSC marker CD133 were highly expressed in gefitinib-resistant persisters (GRPs) in...

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Identifiers

PMID: 26996130
DOI: 10.1016/j.bbrc.2016.03.064

Genes

EGFR
NOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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