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Article

Detection ofTP53R249 Mutation in Iranian Patients with Pancreatic Cancer

1 Jan 2013

Abstract excerpt

The TP53 gene encodes tumor protein p53 which play a major role in the etiology of pancreatic cancer. The important role of codon 249 of TP53 for binding of p53 to its sequence-specific consensus site in DNA has been revealed by crystallography's studies, and mutation at this codon was detected in the plasma of some human cancers. The TP53 Mut assessor software within the International Agency for Research on...

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PMID: 24489544
DOI: 10.1155/2013/738915

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