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Article

Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment

31 Jan 2014

Abstract excerpt

Insidious changes in behaviour herald the onset of progressive neurodegenerative disorders such as Huntington's disease (HD), sometimes years before overt symptoms are seen. Sleep and circadian disturbances are particularly disruptive symptoms in patients with neurological disorders, but they are difficult to measure in humans. Here we studied circadian behaviour in transgenic HD sheep expressing the full-length...

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PMID: 24488771
DOI: 10.1093/hmg/ddu047

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