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Article

Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.

Brain : a journal of neurology - 1 Jul 2013

Fisher Simon P, Black Sarah W, Schwartz Michael D, Wilk Alan J, Chen Tsui-Ming, Lincoln Webster U, Liu Helen W, Kilduff Thomas S, Morairty Stephen R

Abstract excerpt

Deficits in sleep and circadian organization have been identified as common early features in patients with Huntington's disease that correlate with symptom severity and may be instrumental in disease progression. Studies in Huntington's disease gene carriers suggest that alterations in the electroencephalogram may reflect underlying neuronal dysfunction that is present in the premanifest stage. We conducted a...

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PMID: 23801738
DOI: 10.1093/brain/awt132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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