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Article

The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep.

PloS one - 1 Jan 2013

Loh Dawn H, Kudo Takashi, Truong Danny, Wu Yingfei, Colwell Christopher S

Abstract excerpt

Sleep and circadian disruptions are commonly reported by patients with neurodegenerative diseases, suggesting these may be an endophenotype of the disorders. Several mouse models of Huntington's disease (HD) that recapitulate the disease progression and motor dysfunction of HD also exhibit sleep...

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Identifiers

PMID: 23936129
DOI: 10.1371/journal.pone.0069993
PMCID: PMC3728350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23936129-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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