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Article

Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism.

The Journal of clinical endocrinology and metabolism - 1 Apr 2014

Salian-Mehta S, Xu M, Knox A J, Plummer L, Slavov D, Taylor M, Bevers S, Hodges R S, Crowley W F, Wierman M E

Abstract excerpt

CONTEXT: Prior studies showed that Axl /Tyro3 null mice have delayed first estrus and abnormal cyclicity due to developmental defects in GnRH neuron migration and survival. OBJECTIVE: The objective of the study was to test whether the absence of Axl would alter reproductive function in mice and that mutations in AXL are present in patients with Kallmann syndrome (KS) or normosmic idiopathic hypogonadotropic...

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Source

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Identifiers

PMID: 24476074
DOI: 10.1210/jc.2013-3426
PMCID: PMC3973777

Genes

AXL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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