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Article

Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice.

Human molecular genetics - 1 Jun 2017

Marcos Séverine, Monnier Carine, Rovira Xavier, Fouveaut Corinne, Pitteloud Nelly, Ango Fabrice, Dodé Catherine, Hardelin Jean-Pierre

Abstract excerpt

The olfacto-genital syndrome (Kallmann syndrome) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. This is a genetically heterogeneous developmental disease with various modes of transmission, including oligogenic inheritance. Previous reports have involved defective cell signaling by semaphorin-3A in the disease pathogenesis. Here, we report that the...

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Source

Identifiers

PMID: 28334861
DOI: 10.1093/hmg/ddx080

Genes

PLXNA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice.PMID 28334861Read ↗

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