Article
Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in a mouse model of sleep apnea.
American journal of respiratory and critical care medicine - 1 Mar 2014
Almendros Isaac, Wang Yang, Becker Lev, Lennon Frances E, Zheng Jiamao, Coats Brittney R, Schoenfelt Kelly S, Carreras Alba, Hakim Fahed, Zhang Shelley X, Farré Ramon, Gozal David
Abstract excerpt
RATIONALE: An increased cancer aggressiveness and mortality have been recently reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, enhances melanoma growth and metastasis in mice. OBJECTIVES: To assess whether OSA-related adverse cancer outcomes occur via IH-induced changes in host immune responses, namely tumor-associated macrophages (TAMs). MEASUREMENTS AND...
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