Article
High prevalence of GPRC5A germline mutations in BRCA1-mutant breast cancer patients.
International journal of cancer - 15 May 2014
Sokolenko Anna P, Bulanova Daria R, Iyevleva Aglaya G, Aleksakhina Svetlana N, Preobrazhenskaya Elena V, Ivantsov Alexandr O, Kuligina Ekatherina Sh, Mitiushkina Natalia V, Suspitsin Evgeny N, Yanus Grigoriy A, Zaitseva Olga A, Yatsuk Olga S, Togo Alexandr V, Kota Poojitha, Dixon J Michael, Larionov Alexey A, Kuznetsov Sergey G, Imyanitov Evgeny N
Abstract excerpt
In a search for new breast cancer (BC) predisposing genes, we performed a whole exome sequencing analysis using six patient samples of familial BC and identified a germline inactivating mutation c.183delG [p. Arg61fs] in an orphan G protein-coupled receptor GPRC5A. An extended case-control study revealed a tenfold enrichment for this mutation in BC patients carrying the 5382insC allele of BRCA1, the major founder...
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