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Article

MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinoma.

PloS one - 1 Jan 2014

Lacroix Ludovic, Post Sophie F, Valent Alexander, Melkane Antoine E, Vielh Philippe, Egile Coumaran, Castell Christelle, Larois Christelle, Micallef Sandrine, Saulnier Patrick, Goulaouic Hélène, Lefebvre Anne-Marie, Temam Stéphane

Abstract excerpt

BACKGROUND: Identification of MET genetic alteration, mutation, or amplification in oropharyngeal squamous cell carcinoma (OPSCC) could lead to development of MET selective kinase inhibitors. The aim of this study was to assess the frequency and prognostic value of MET gene mutation, amplification, and protein expression in primary OPSCC. METHODS: A retrospective chart review was conducted of patients treated for...

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Share to Carcinoma, Squamous Cell
Share to Chromosomes, Human, Pair 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to In Situ Hybridization, Fluorescence

Share to Oropharyngeal Neoplasms

Share to Patient Selection

Share to Proto-Oncogene Proteins c-met

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 24465403
DOI: 10.1371/journal.pone.0084319
PMCID: PMC3894941

Genes

MET

Variants

Provenance

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