Clinical and prognostic implications of ALK and ROS1 rearrangements in never-smokers with surgically resected lung adenocarcinoma.

doi:10.1016/j.lungcan.2014.01.003

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Article

Clinical and prognostic implications of ALK and ROS1 rearrangements in never-smokers with surgically resected lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2014

Kim Min Hwan, Shim Hyo Sup, Kang Dae Ryong, Jung Ji Ye, Lee Chang Young, Kim Dae Joon, Lee Jin Gu, Bae Mi Kyung, Kim Hye Ryun, Lim Sun Min, Kim Eun Young, Park Ji Soo, Chung Kyung Young, Kim Hyun-Jung, Kim Joo Hang, Cho Byoung Chul

Abstract excerpt

OBJECTIVES: The aim of this study is to evaluate the prevalence and prognostic significance of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) rearrangement in never-smokers with surgically resected lung adenocarcinoma. METHODS: We retrospectively analyzed 162 consecutive never-smokers who underwent curative resection for stage IB to IIIA lung adenocarcinoma at a single institution. We concurrently...

Topics

Adenocarcinoma
Anaplastic Lymphoma Kinase
DNA Mutational Analysis
ErbB Receptors
Gene Rearrangement
Lung Neoplasms
Mutation
Neoplasm Staging
Pneumonectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins p21(ras)

Receptor Protein-Tyrosine Kinases

Recurrence

Retrospective Studies

Smoking

Survival Analysis

ras Proteins

Source

Open in PubMed

Identifiers

PMID: 24462463
DOI: 10.1016/j.lungcan.2014.01.003

Genes

ALK
ROS1
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24462463-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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