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Article

Calcitonin gene-related peptide restores disrupted excitation-contraction coupling in myotubes expressing central core disease mutations in RyR1.

The Journal of physiology - 1 Oct 2011

Vega Ana Victoria, Ramos-Mondragón Roberto, Calderón-Rivera Aida, Zarain-Herzberg Angel, Avila Guillermo

Abstract excerpt

Central core disease (CCD) is a congenital human myopathy associated with mutations in the gene encoding the skeletal muscle ryanodine receptor (RyR1), resulting in skeletal muscle weakness and lower limb deformities. The muscle weakness can be at least partially explained by a reduced magnitude of voltage-gated Ca(2+) release (VGCR). To date, only a few studies have focused on identifying potential therapeutic...

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Identifiers

PMID: 21825032
DOI: 10.1113/jphysiol.2011.210765
PMCID: PMC3213414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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