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Article

Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis.

PloS one - 1 Jan 2014

Ishtiaq Muhammad, Campos-Melo Danae, Volkening Kathryn, Strong Michael J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motor neuron degeneration and neurofilament aggregate formation. Spinal motor neurons in ALS also show a selective suppression in the levels of low molecular weight neurofilament (NEFL) mRNA. We have been interested in investigating the role of microRNAs (miRNAs) in NEFL transcript stability. MiRNAs are small, 20-25 nucleotide,...

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Identifiers

PMID: 24454911
DOI: 10.1371/journal.pone.0085653
PMCID: PMC3893244

Genes

NEFL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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