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Article

Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro.

Molecular biology of the cell - 1 Jul 2005

Chen Xiaoping, Mao Zebin, Liu Shuhong, Liu Hong, Wang Xuan, Wu Haitao, Wu Yan, Zhao Tong, Fan Wenhong, Li Yong, Yew David T, Kindler Pawel M, Li Linsong, He Qihua, Qian Lingjia, Wang Xiaomin, Fan Ming

Abstract excerpt

Ciliary neurotrophic factor (CNTF) is primarily known for its important cellular effects within the nervous system. However, recent studies indicate that its receptor can be highly expressed in denervated skeletal muscle. Here, we investigated the direct effect of CNTF on skeletal myoblasts of adult human. Surprisingly, we found that CNTF induced the myogenic lineage-committed myoblasts at a clonal level to...

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Identifiers

PMID: 15843428
DOI: 10.1091/mbc.e05-03-0218
PMCID: PMC1165399

Genes

CNTF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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