Article
Identification of nitrated tyrosine residues of protein kinase G-Iα by mass spectrometry.
Analytical and bioanalytical chemistry - 1 Feb 2014
Lu Jingshan, Yao Ikuko, Shimojo Masahito, Katano Tayo, Uchida Hitoshi, Setou Mitsutoshi, Ito Seiji
Abstract excerpt
The nitration of tyrosine to 3-nitrotyrosine is an oxidative modification of tyrosine by nitric oxide and is associated with many diseases, and targeting of protein kinase G (PKG)-I represents a potential therapeutic strategy for pulmonary hypertension and chronic pain. The direct assignment of tyrosine residues of PKG-I has remained to be made due to the low sensitivity of the current proteomic approach. In...
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