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Article

Effect of lysine to alanine mutations on the phosphate activation and BPTES inhibition of glutaminase.

Neurochemistry international - 1 Sept 2015

McDonald Charles J, Acheff Eric, Kennedy Ryan, Taylor Lynn, Curthoys Norman P

Abstract excerpt

The GLS1 gene encodes a mitochondrial glutaminase that is highly expressed in brain, kidney, small intestine and many transformed cells. Recent studies have identified multiple lysine residues in glutaminase that are sites of N-acetylation. Interestingly, these sites are located within either a loop segment that regulates access of glutamine to the active site or the dimer:dimer interface that participates in the...

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Identifiers

PMID: 25510640
DOI: 10.1016/j.neuint.2014.12.003
PMCID: PMC4465886

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