Article

Kaposi’s Sarcoma-associated Herpesvirus ORF21 Enhances the Phosphorylation of MEK and the Infectivity of Progeny Virus

2022-11-25

Abstract excerpt

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, is the causative agent of Kaposi’s sarcoma, Castleman’s disease, and primary effusion lymphoma. Although the functions of the viral thymidine kinases (vTK) of herpes simplex virus-1/2 and varicella zoster virus are well understood, that of KSHV ORF21 (an ortholog of vTK) is largely unknown. Here, we investigated th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0d0c2a6-a5b0-5180-992a-4048c0b67b31
DOI: 10.20944/preprints202211.0470.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kaposi’s Sarcoma-associated Herpesvirus ORF21 Enhances the Phosphorylation of MEK and the Infectivity of Progeny VirusDOI 10.20944/preprints202211.0470.v1Read

Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use.Semantic proximity Read

Kaposi’s sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus productionSemantic proximity Read

Molecular virology of Kaposi's sarcoma–associated herpesvirusSemantic proximity Read

Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Thymidine Kinase (ORF21) by X-Box Binding Protein 1.Semantic proximity Read

Oncogenic Mechanisms of Kaposi's Sarcoma‐Associated Herpesvirus on Cell Metabolism and Cell TransformationSemantic proximity Read

Identification and Characterization of the Orf49 Protein of Kaposi's Sarcoma-Associated HerpesvirusSemantic proximity Read

Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Proliferation of SH-SY5Y Cells by the Notch Signaling PathwaySemantic proximity Read

Kaposi’s sarcoma-associated herpesvirus ORF67.5 functions as a component of the terminase complexSemantic proximity Read

Kaposi's Sarcoma-Associated Herpesvirus-Encoded Protein Kinase and Its Interaction with K-bZIPSemantic proximity Read

A Survey of the Interactome of Kaposi's Sarcoma-Associated Herpesvirus ORF45 Revealed Its Binding to Viral ORF33 and Cellular USP7, Resulting in Stabilization of ORF33 That Is Required for Production of Progeny VirusesSemantic proximity Read

Activation of p90 Ribosomal S6 Kinases by ORF45 of Kaposi's Sarcoma-Associated Herpesvirus Is Critical for Optimal Production of Infectious VirusesSemantic proximity Read

Kaposi's sarcoma-associated herpesvirus ORF6 gene is essential in viral lytic replication.Semantic proximity Read