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Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV

1 Feb 2012

Abstract excerpt

Infections by viruses are associated with approximately 12% of human cancer. Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several malignancies commonly found in AIDS patients. The mechanism of KSHV-induced oncogenesis remains elusive, due in part to the lack of an adequate experimental system for cellular transformation of primary cells. Here, we report efficient infection and cellular...

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PMID: 22293176
DOI: 10.1172/jci58530

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