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Article

Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.

PLoS genetics - 1 Jan 2022

Tanaka Karo, Besson Vanessa, Rivagorda Manon, Oury Franck, Marazzi Giovanna, Sassoon David A

Abstract excerpt

The paternally expressed gene 3 (Pw1/Peg3) is a mammalian-specific parentally imprinted gene expressed in stem/progenitor cells of the brain and endocrine tissues. Here, we compared phenotypic characteristics in Pw1/Peg3 deficient male and female mice. Our findings indicate that Pw1/Peg3 is a key player for the determination of sexual dimorphism in metabolism and behavior. Mice carrying a paternally inherited...

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Identifiers

PMID: 35025875
DOI: 10.1371/journal.pgen.1010003
PMCID: PMC8791484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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