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Article

PinX1, a novel target gene of p53, is suppressed by HPV16 E6 in cervical cancer cells.

Biochimica et biophysica acta - 1 Feb 2014

Wu Gengze, Liu Dongbo, Jiang Ke, Zhang Li, Zeng Yijun, Zhou Peng, Zhong Dan, Gao Min, He Fengtian, Zheng Yingru

Abstract excerpt

The aberrant activation of telomerase is critical for the initiation and development of human cervical cancer, which is dependent on the activation of human telomerase reverse transcriptase (hTERT). Recently, Pin2/TRF1-interacting protein X1 (PinX1) has been identified as a suppressor of hTERT. It has been found that the telomerase is activated while the level of PinX1 is decreased in cervical cancer. However,...

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Identifiers

PMID: 24412852
DOI: 10.1016/j.bbagrm.2014.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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PinX1, a novel target gene of p53, is suppressed by HPV16 E6 in cervical cancer cells.PMID 24412852Read ↗

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual RolesSemantic proximity Read ↗

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The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceSemantic proximity Read ↗

Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer CellsSemantic proximity Read ↗

The telomere/telomerase binding factor <scp>PinX1</scp> is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomasSemantic proximity Read ↗

MiR‐17‐5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cellsSemantic proximity Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

Expression of HPV-16 E6 Protein and p53 Inactivation Increases the Uterine Cervical Cancer InvasionSemantic proximity Read ↗

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Human papillomavirus 16 E6 modulates the expression of host microRNAs in cervical cancerSemantic proximity Read ↗

PITX1 protein interacts with ZCCHC10 to regulate <i>hTERT</i> mRNA transcriptionSemantic proximity Read ↗

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