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Article

Engineering cells with intracellular agent-loaded microparticles to control cell phenotype.

Nature protocols - 1 Feb 2014

Ankrum James A, Miranda Oscar R, Ng Kelvin S, Sarkar Debanjan, Xu Chenjie, Karp Jeffrey M

Abstract excerpt

Cell therapies enable unprecedented treatment options to replace tissues, destroy tumors and facilitate regeneration. The greatest challenge facing cell therapy is the inability to control the fate and function of cells after transplantation. We have developed an approach to control cell phenotype in vitro and after transplantation by engineering cells with intracellular depots that continuously release...

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Identifiers

PMID: 24407352
DOI: 10.1038/nprot.2014.002
PMCID: PMC4320648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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