Article
The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells.
International immunology - 1 Jun 2014
Looi Chung Yeng, Sasahara Yoji, Watanabe Yuko, Satoh Miki, Hakozaki Ikuko, Uchiyama Meri, Wong Won Fen, Du Wei, Uchiyama Toru, Kumaki Satoru, Tsuchiya Shigeru, Kure Shigeo
Abstract excerpt
Mutations in the gene encoding the Wiskott-Aldrich syndrome protein (WASP) are responsible for Wiskott-Aldrich syndrome and WASP is a major actin regulator in the cytoplasm. Although rare gain-of-function mutations in the WASP gene are known to result in X-linked neutropenia (XLN), the molecular pathogenesis of XLN is not fully understood. In this study, we showed that all reported constitutively activating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.